Tat-haFGF14-154 Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1α/XBP1 Pathway

• Main Authors: Tian Meng (Author), Qin Cao (Author), Peng Lei (Author), Ashley I. Bush (Author), Qi Xiang (Author), Zhijian Su (Author), Xiang He (Author), Jack T. Rogers (Author), Ing-Ming Chiu (Author), Qihao Zhang (Author), Yadong Huang (Author)
• Format: Book
• Published: Elsevier, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acid fibroblast growth factor (aFGF) has shown neuroprotection in Alzheimer's disease (AD) models in previous studies, yet its mechanism is still uncertain. Here we report that the efficacy of Tat-haFGF14-154 is markedly increased when loaded cationic liposomes for intranasal delivery are intra...