A proteomic landscape of pharmacologic perturbations for functional relevance

• Main Authors: Zhiwei Liu (Author), Shangwen Jiang (Author), Bingbing Hao (Author), Shuyu Xie (Author), Yingluo Liu (Author), Yuqi Huang (Author), Heng Xu (Author), Cheng Luo (Author), Min Huang (Author), Minjia Tan (Author), Jun-Yu Xu (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pharmacological perturbation studies based on protein-level signatures are fundamental for drug discovery. In the present study, we used a mass spectrometry (MS)-based proteomic platform to profile the whole proteome of the breast cancer MCF7 cell line under stress induced by 78 bioactive compounds....