The roles of serine hydrolases and serum albumin in alisol B 23-acetate hydrolysis in humans

• Main Authors: Tiantian Zhang (Author), Feng Zhang (Author), Yani Zhang (Author), Hongxin Li (Author), Guanghao Zhu (Author), Taotao Weng (Author), Cheng Huang (Author), Ping Wang (Author), Yuqi He (Author), Jing Hu (Author), Guangbo Ge (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Alisol B 23-acetate (AB23A), a major bioactive constituent in the Chinese herb Zexie (Rhizoma Alismatis), has been found with multiple pharmacological activities. AB23A can be readily hydrolyzed to alisol B in mammals, but the hydrolytic pathways of AB23A in humans and the key enzymes...