Sensorimotor Gating Impairments Induced by MK-801 Treatment may be Reduced by Tolerance Effect and by Familiarization in Monkeys

• Principais autores: Patricia G Saletti (Autor), Rafael S Maior (Autor), Etsuro eHori (Autor), Hisao eNishijo (Autor), Carlos eTomaz (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2015-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Dizocilpine (MK-801) is a noncompetitive NMDA antagonist that induces schizophrenic-like effects. It is therefore widely used in experimental models of schizophrenia including prepulse inhibition (PPI) impairments in rodents. Nevertheless, MK-801 has never been tested in monkeys on a PPI paradigm. I...