Sensorimotor Gating Impairments Induced by MK-801 Treatment may be Reduced by Tolerance Effect and by Familiarization in Monkeys

Sensorimotor Gating Impairments Induced by MK-801 Treatment may be Reduced by Tolerance Effect and by Familiarization in Monkeys

Dizocilpine (MK-801) is a noncompetitive NMDA antagonist that induces schizophrenic-like effects. It is therefore widely used in experimental models of schizophrenia including prepulse inhibition (PPI) impairments in rodents. Nevertheless, MK-801 has never been tested in monkeys on a PPI paradigm. I...

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Main Authors: Patricia G Saletti (Author), Rafael S Maior (Author), Etsuro eHori (Author), Hisao eNishijo (Author), Carlos eTomaz (Author)
Format: Book
Published: Frontiers Media S.A., 2015-09-01T00:00:00Z.
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3rd Floor Main Library

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