A Whole-Body Physiologically Based Pharmacokinetic Model Characterizing Interplay of OCTs and MATEs in Intestine, Liver and Kidney to Predict Drug-Drug Interactions of Metformin with Perpetrators

• Principais autores: Yiting Yang (Autor), Zexin Zhang (Autor), Ping Li (Autor), Weimin Kong (Autor), Xiaodong Liu (Autor), Li Liu (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2021-05-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Transmembrane transport of metformin is highly controlled by transporters including organic cation transporters (OCTs), plasma membrane monoamine transporter (PMAT), and multidrug/toxin extrusions (MATEs). Hepatic OCT1, intestinal OCT3, renal OCT2 on tubule basolateral membrane, and MATE1/2-K on tub...