A novel Cre-enabled tetracycline-inducible transgenic system for tissue-specific cytokine expression in the zebrafish: CETI-PIC3

• Main Authors: Sara Ibrahim (Author), Arianna Harris-Kawano (Author), Isra Haider (Author), Raghavendra G. Mirmira (Author), Emily K. Sims (Author), Ryan M. Anderson (Author)
• 格式: 图书
• 出版: The Company of Biologists, 2020-06-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Maladaptive signaling by pro-inflammatory cytokines (PICs), such as TNFα, IL1β and IFNɣ, can activate downstream signaling cascades that are implicated in the development and progression of multiple inflammatory diseases. Despite playing critical roles in pathogenesis, the availability of in vivo mo...