An Angiopep2-PAPTP Construct Overcomes the Blood-Brain Barrier. New Perspectives against Brain Tumors

• Main Authors: Sofia Parrasia (Author), Andrea Rossa (Author), Tatiana Varanita (Author), Vanessa Checchetto (Author), Riccardo De Lorenzi (Author), Mario Zoratti (Author), Cristina Paradisi (Author), Paolo Ruzza (Author), Andrea Mattarei (Author), Ildikò Szabò (Author), Lucia Biasutto (Author)
• Format: Book
• Published: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A developing family of chemotherapeutics-derived from 5-(4-phenoxybutoxy)psoralen (PAP-1)-target mitochondrial potassium channel mtKv1.3 to selectively induce oxidative stress and death of diseased cells. The key to their effectiveness is the presence of a positively charged triphenylphosphonium gro...