Sodium Overload Due To a Persistent Current That Attenuates The Arrhythmogenic Potential of a Novel LQT3 Mutation

• Main Authors: Adrien eMoreau (Author), Andrew D Krahn (Author), Pascal eGosselin-Badaroudine (Author), George J Klein (Author), Georges eChristé (Author), Yohann eVincent (Author), Mohamed eBoutjdir (Author), Mohamed eChahine (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Long QT syndrome (LQTS) is a congenital abnormality of cardiac repolarization that manifests as a prolonged QT interval on 12-lead electrocardiograms. The syndrome may lead to syncope and sudden death from ventricular tachyarrhythmias known as torsades de pointes. An increased persistent Na+ current...