Cutaneous C-polymodal fibers lacking TRPV1 are sensitized to heat following inflammation, but fail to drive heat hyperalgesia in the absence of TPV1 containing C-heat fibers

• Glavni autori: Koerber H Richard (Autor), McIlwrath Sabrina L (Autor), Lawson Jeffrey J (Autor), Malin Sacha A (Autor), Anderson Collene E (Autor), Jankowski Michael P (Autor), Davis Brian M (Autor)
• Format: Knjiga
• Izdano: SAGE Publishing, 2010-09-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Previous studies have shown that the TRPV1 ion channel plays a critical role in the development of heat hyperalgesia after inflammation, as inflamed TRPV1-/- mice develop mechanical allodynia but fail to develop thermal hyperalgesia....