Cutaneous C-polymodal fibers lacking TRPV1 are sensitized to heat following inflammation, but fail to drive heat hyperalgesia in the absence of TPV1 containing C-heat fibers

• Main Authors: Koerber H Richard (Author), McIlwrath Sabrina L (Author), Lawson Jeffrey J (Author), Malin Sacha A (Author), Anderson Collene E (Author), Jankowski Michael P (Author), Davis Brian M (Author)
• Format: Book
• Published: SAGE Publishing, 2010-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Previous studies have shown that the TRPV1 ion channel plays a critical role in the development of heat hyperalgesia after inflammation, as inflamed TRPV1-/- mice develop mechanical allodynia but fail to develop thermal hyperalgesia....