Deficiency of autoimmune regulator impairs the immune tolerance effect of bone marrow-derived dendritic cells in mice

• Päätekijät: Feifei Huo (Tekijä), Dongbei Li (Tekijä), Bo Zhao (Tekijä), Yadong Luo (Tekijä), Bingjie Zhao (Tekijä), Xueyang Zou (Tekijä), Yi Li (Tekijä), Wei Yang (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

As a transcription factor, autoimmune regulator (Aire) participates in thymic negative selection and maintains immune tolerance mainly by regulating the ectopic expression of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs). Aire is also expressed in dendritic cells (DC...