Adenosine-A2A Receptor Signaling Plays a Crucial Role in Sudden Unexpected Death in Epilepsy

• Main Authors: Hai-Ying Shen (Author), Sadie B. Baer (Author), Raey Gesese (Author), John M. Cook (Author), Landen Weltha (Author), Shayla Q. Coffman (Author), Jie Wu (Author), Jiang-Fan Chen (Author), Ming Gao (Author), Teng Ji (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adenosinergic activities are suggested to participate in SUDEP pathophysiology; this study aimed to evaluate the adenosine hypothesis of SUDEP and specifically the role of adenosine A2A receptor (A2AR) in the development of a SUDEP mouse model with relevant clinical features. Using a combined paradi...