A single ascending dose study of single‐stranded oligodeoxyribonucleotide RO7062931 in Chinese healthy volunteers

• Main Authors: Tsang Tommy Cheung (Author), Andrea On Yan Luk (Author), Yuchen Zhang (Author), Vedran Pavlovic (Author), Cynthia Wat (Author), Sudip Das (Author), Bernadette Surujbally (Author), Miriam Triyatni (Author), Joseph F. Grippo (Author)
• Format: Book
• Published: Wiley, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract RO7062931 is an N‐acetylgalactosamine (GalNAc)‐conjugated single‐stranded oligodeoxyribonucleotide complementary to hepatitis B virus RNA. GalNAc conjugation targets the liver through the asialoglycoprotein receptor (ASGPR). This phase I single ascending dose (SAD) study evaluated the safet...