Inhibition of 6-phosphogluconate Dehydrogenase Reverses Cisplatin Resistance in Ovarian and Lung Cancer

• Main Authors: Wujian Zheng (Author), Qi Feng (Author), Jiao Liu (Author), Yanke Guo (Author), Lvfen Gao (Author), Ruiman Li (Author), Meng Xu (Author), Guizhen Yan (Author), Zhinan Yin (Author), Shuai Zhang (Author), Shuangping Liu (Author), Changliang Shan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cisplatin (DDP) is currently one of the most commonly used chemotherapeutic drugs for treating ovarian and lung cancer. However, resistance to cisplatin is common and it often leads to therapy failure. In addition, the precise mechanism of cisplatin resistance is still in its infancy. In this study,...