Design, Synthesis, In Silico Studies and In Vitro Evaluation of New Indole- and/or Donepezil-like Hybrids as Multitarget-Directed Agents for Alzheimer's Disease

• Main Authors: Violina T. Angelova (Author), Borislav Georgiev (Author), Tania Pencheva (Author), Ilza Pajeva (Author), Miroslav Rangelov (Author), Nadezhda Todorova (Author), Dimitrina Zheleva-Dimitrova (Author), Elena Kalcheva-Yovkova (Author), Iva V. Valkova (Author), Nikolay Vassilev (Author), Rositsa Mihaylova (Author), Denitsa Stefanova (Author), Boris Petrov (Author), Yulian Voynikov (Author), Virginia Tzankova (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease (AD) is considered a complex neurodegenerative condition which warrants the development of multitargeted drugs to tackle the key pathogenetic mechanisms of the disease. In this study, two novel series of melatonin- and donepezil-based hybrid molecules with hydrazone (<b&g...