MicroRNA-29a Mitigates Osteoblast Senescence and Counteracts Bone Loss through Oxidation Resistance-1 Control of FoxO3 Methylation

• Main Authors: Wei-Shiung Lian (Author), Re-Wen Wu (Author), Yu-Shan Chen (Author), Jih-Yang Ko (Author), Shao-Yu Wang (Author), Holger Jahr (Author), Feng-Sheng Wang (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Senescent osteoblast overburden accelerates bone mass loss. Little is understood about microRNA control of oxidative stress and osteoblast senescence in osteoporosis. We revealed an association between microRNA-29a (<i>miR-29a</i>) loss, oxidative stress marker 8-hydroxydeoxyguanosine (8...