Direct Interaction between <i>N</i>-Acetylcysteine and Cytotoxic Electrophile-An Overlooked In Vitro Mechanism of Protection
In laboratory experiments, many electrophilic cytotoxic agents induce cell death accompanied by reactive oxygen species (ROS) production and/or by glutathione (GSH) depletion. Not surprisingly, millimolar concentrations of <i>N</i>-acetylcysteine (NAC), which is used as a universal ROS s...
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MDPI AG,
2022-07-01T00:00:00Z.
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