Evaluation of acute toxicity of β-lapachone associated with chitosan as a cytoprotective agent

• Main Authors: Maria Eduarda F. A. G. Oliveira (Author), Érika Cristina G. M. Silva (Author), Celso A. Câmara (Author), Ivone Antônia de Souza (Author), Rosa Valéria S. Amorim (Author)
• Format: Book
• Published: Sociedade Brasileira de Patologia Clínica, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT INTRODUCTION: β-lapachone (β-LAP), a potent antitumor agent, has limited therapeutic use due to its low solubility and high toxicity. A possible strategy to overcome these drawbacks may be the use of adjuvants such as chitosan (CS), a cationic polysaccharide with biological properties of bi...