Posttranscriptional Suppression of Lipopolysaccharide-Stimulated Inflammatory Responses by Macrophages in Middle-Aged Mice: A Possible Role for Eukaryotic Initiation Factor 2α

• Main Authors: Ken Shirato (Author), Kazuhiko Imaizumi (Author)
• Formato: Libro
• Publicado: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

The intensities of macrophage inflammatory responses to bacterial components gradually decrease with age. Given that a reduced rate of protein synthesis is a common age-related biochemical change, which is partially mediated by increased phosphorylation of eukaryotic initiation factor-2α (eIF-2α), w...