HMGB1 and its membrane receptors as therapeutic targets in an intravesical substance P-induced bladder pain syndrome mouse model

• Main Authors: Yuhei Irie (Author), Maho Tsubota (Author), Mariko Maeda (Author), Shiori Hiramoto (Author), Fumiko Sekiguchi (Author), Hiroyasu Ishikura (Author), Hidenori Wake (Author), Masahiro Nishibori (Author), Atsufumi Kawabata (Author)
• Format: Book
• Published: Elsevier, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

HMGB1, a nuclear protein, once released to the extracellular space, promotes somatic and visceral pain signals. We thus analyzed the role of HMGB1 in an intravesical substance P-induced bladder pain syndrome (BPS) mouse model. Intravesical administration of substance P caused referred hyperalgesia/a...