Computational Design and Biological Evaluation of Analogs of Lupin Peptide P5 Endowed with Dual PCSK9/HMG-CoAR Inhibiting Activity

• Main Authors: Carmen Lammi (Author), Enrico M. A. Fassi (Author), Jianqiang Li (Author), Martina Bartolomei (Author), Giulia Benigno (Author), Gabriella Roda (Author), Anna Arnoldi (Author), Giovanni Grazioso (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

(1) Background: Proprotein convertase subtilisin/kexin 9 (PCSK9) is responsible for the degradation of the hepatic low-density lipoprotein receptor (LDLR), which regulates the circulating cholesterol level. In this field, we discovered natural peptides derived from lupin that showed PCSK9 inhibitory...