Negative chronotropic and inotropic effects of lubiprostone on iPS cell-derived cardiomyocytes via activation of CFTR

Abstract Background Lubiprostone (LBP) is a novel chloride channel opener that has been reported to activate chloride channel protein 2 (ClC-2) and cystic fibrosis transmembrane conductance regulator (CFTR). LBP facilitates fluid secretion by activating CFTR in the intestine and is used as a drug fo...

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Bibliographic Details
Main Authors: Hiraku Akita (Author), Susumu Yoshie (Author), Takafumi Ishida (Author), Yasuchika Takeishi (Author), Akihiro Hazama (Author)
Format: Book
Published: BMC, 2020-04-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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