Negative chronotropic and inotropic effects of lubiprostone on iPS cell-derived cardiomyocytes via activation of CFTR

• المؤلفون الرئيسيون: Hiraku Akita (مؤلف), Susumu Yoshie (مؤلف), Takafumi Ishida (مؤلف), Yasuchika Takeishi (مؤلف), Akihiro Hazama (مؤلف)
• التنسيق: كتاب
• منشور في: BMC, 2020-04-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract Background Lubiprostone (LBP) is a novel chloride channel opener that has been reported to activate chloride channel protein 2 (ClC-2) and cystic fibrosis transmembrane conductance regulator (CFTR). LBP facilitates fluid secretion by activating CFTR in the intestine and is used as a drug fo...