Directly targeting BAX for drug discovery: Therapeutic opportunities and challenges

• Main Authors: Zhenwei Zhang (Author), Linghui Hou (Author), Dan Liu (Author), Shenglin Luan (Author), Min Huang (Author), Linxiang Zhao (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

For over two decades, the development of B-cell lymphoma-2 (Bcl-2) family therapeutics has primarily focused on anti-apoptotic proteins, resulting in the first-in-class drugs called BH3 mimetics, especially for Bcl-2 inhibitor Venetoclax. The pro-apoptotic protein Bcl-2-associated X protein (BAX) pl...