A first‐in‐human study of KMRC011, a potential treatment for acute radiation syndrome, to explore tolerability, pharmacokinetics, and pharmacodynamics

• Main Authors: Eunsol Yang (Author), Hyejung Choi (Author), Jin‐Sol Park (Author), Young‐Woock Noh (Author), Chi‐Min Choi (Author), Woo‐Jong Lee (Author), Jae‐Wook Ko (Author), Jungryul Kim (Author)
• Format: Book
• Published: Wiley, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract KMRC011 is a novel Toll‐like receptor 5 agonist under development as a treatment for acute radiation syndrome (ARS). The aim of this first‐in‐human study was to investigate the tolerability, pharmacokinetics, and pharmacodynamics of a single intramuscular dose of KMRC011 in healthy subjects...