Targeting IKKβ Activity to Limit Sterile Inflammation in Acetaminophen-Induced Hepatotoxicity in Mice

• Main Authors: Song-Hee Kim (Author), Da-Eun Jung (Author), Jin Yong Song (Author), Jihye Jung (Author), Jae-Kyung Jung (Author), Heesoon Lee (Author), Eunmiri Roh (Author), Jin Tae Hong (Author), Sang-Bae Han (Author), Youngsoo Kim (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The kinase activity of inhibitory κB kinase β (IKKβ) acts as a signal transducer in the activating pathway of nuclear factor-κB (NF-κB), a master regulator of inflammation and cell death in the development of numerous hepatocellular injuries. However, the importance of IKKβ activity on acetaminophen...