No mutations found in exons of TP53, H-RAS and K-RAS genes in liver of male Wistar rats submitted to a medium-term chemical carcinogenesis assay

• Main Authors: Erick da Cruz Castelli (Author), Andréia Hanada Otake (Author), Deilson Elgui de Oliveira (Author), Noeme Souza Rocha (Author), Daisy Maria Fávero Salvadori (Author), João Lauro Viana de Camargo (Author)
• Format: Book
• Published: Sociedade Brasileira de Patologia Clínica, 2002-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The standard protocol to evaluate the carcinogenic potential of chemicals is the long-term bioassay in rodents, not performed in developing countries due to its high cost and complex operational procedures. Our laboratory has established an alternative medium-term bioassay in Wistar rats, also calle...