Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols.

• Main Authors: Juliana B R Corrêa Soares (Author), Diego Menezes (Author), Marcos A Vannier-Santos (Author), Antonio Ferreira-Pereira (Author), Giulliana T Almeida (Author), Thiago M Venancio (Author), Sergio Verjovski-Almeida (Author), Vincent K Zishiri (Author), David Kuter (Author), Roger Hunter (Author), Timothy J Egan (Author), Marcus F Oliveira (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: The parasitic trematode Schistosoma mansoni is one of the major causative agents of human schistosomiasis, which afflicts 200 million people worldwide. Praziquantel remains the main drug used for schistosomiasis treatment, and reliance on the single therapy has been prompting the search...