Optimization of Thymoquinone-Loaded Self-Nanoemulsion for Management of Indomethacin-Induced Ulcer

• Autori principali: Mohamed F. Radwan (Autore), Mohamed A. El-Moselhy (Autore), Walied M. Alarif (Autore), Mohamed Orif (Autore), Nabil K. Alruwaili (Autore), Nabil A. Alhakamy (Autore)
• Natura: Libro
• Pubblicazione: SAGE Publishing, 2021-05-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

To improve the water solubility of thymoquinone (TQ), a major constituent of Nigella sativa seed oil, a TQ-loaded self-nanoemulsifying drug delivery system (SNEDDS) was prepared. The SNEDDS formulation was optimized using almond oil (AO) (Oil; X1), tween 80 (surfactant; X2) and polyethylene glycol 2...