Whole Genome Sequencing of Mycobacterium africanum Strains from Mali Provides Insights into the Mechanisms of Geographic Restriction.

• Main Authors: Kathryn Winglee (Author), Abigail Manson McGuire (Author), Mamoudou Maiga (Author), Thomas Abeel (Author), Terrance Shea (Author), Christopher A Desjardins (Author), Bassirou Diarra (Author), Bocar Baya (Author), Moumine Sanogo (Author), Souleymane Diallo (Author), Ashlee M Earl (Author), William R Bishai (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Mycobacterium africanum, made up of lineages 5 and 6 within the Mycobacterium tuberculosis complex (MTC), causes up to half of all tuberculosis cases in West Africa, but is rarely found outside of this region. The reasons for this geographical restriction remain unknown. Possible reasons...