Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells

• Main Authors: Nihal AlMuraikhi (Author), Dalia Ali (Author), Radhakrishnan Vishnubalaji (Author), Muthurangan Manikandan (Author), Muhammad Atteya (Author), Abdulaziz Siyal (Author), Musaad Alfayez (Author), Abdullah Aldahmash (Author), Moustapha Kassem (Author), Nehad M. Alajez (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Chemical biology approaches using small molecule inhibitors targeting specific signaling pathways are useful tools to dissect the molecular mechanisms governing stem cell differentiation and for their possible use in therapeutic interventions. Methods. Stem cell signaling small molecule...