Hu.4-1BB-Fc fusion protein inhibits allergic inflammation and airway hyperresponsiveness in a murine model of asthma

• Autores principales: Byoung-Ju Kim (Autor), Ji-Won Kwon (Autor), Ju-Hee Seo (Autor), Won-Ah Choi (Autor), Young-Jun Kim (Autor), Mi-Jin Kang (Autor), Jinho Yu (Autor), Soo-Jong Hong (Autor)
• Formato: Libro
• Publicado: Korean Pediatric Society, 2011-09-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Purpose4-1BB (CD 137) is a costimulatory molecule expressed on activated T-cells. Repression by 4-1BB is thought to attenuate Th2-mediated allergic reactions. The aim of this study was to investigate the effect of 4-1BB on allergic airway inflammation in a murine asthma model.MethodsBALB/c mice were...