Hu.4-1BB-Fc fusion protein inhibits allergic inflammation and airway hyperresponsiveness in a murine model of asthma

• Main Authors: Byoung-Ju Kim (Author), Ji-Won Kwon (Author), Ju-Hee Seo (Author), Won-Ah Choi (Author), Young-Jun Kim (Author), Mi-Jin Kang (Author), Jinho Yu (Author), Soo-Jong Hong (Author)
• Format: Book
• Published: Korean Pediatric Society, 2011-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose4-1BB (CD 137) is a costimulatory molecule expressed on activated T-cells. Repression by 4-1BB is thought to attenuate Th2-mediated allergic reactions. The aim of this study was to investigate the effect of 4-1BB on allergic airway inflammation in a murine asthma model.MethodsBALB/c mice were...