Combined Heterozygous Genetic Variations in Complement C2 and C8B: An Explanation for Multidimensional Immune Imbalance?

• Үндсэн зохиолчид: Marco Mannes (Зохиогч), Rebecca Halbgebauer (Зохиогч), Lisa Wohlgemuth (Зохиогч), David Alexander Christian Messerer (Зохиогч), Susa Savukoski (Зохиогч), Anke Schultze (Зохиогч), Bettina Berger (Зохиогч), Christiane Leonie Knapp (Зохиогч), Christoph Q. Schmidt (Зохиогч), Daniel Fürst (Зохиогч), Morten Hillmer (Зохиогч), Reiner Siebert (Зохиогч), Oskar Eriksson (Зохиогч), Barbro Persson (Зохиогч), Bo Nilsson (Зохиогч), Kristina Nilsson Ekdahl (Зохиогч), Markus Huber-Lang (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Karger Publishers, 2023-03-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

The complement system plays a crucial role in host defense, homeostasis, and tissue regeneration and bridges the innate and the adaptive immune systems. Although the genetic variants in complement C2 (c.839_849+17del; p.(Met280Asnfs*5)) and C8B (c.1625C>T; p.(Thr542Ile)) are known individually, h...