Hyperoxia Exacerbates Postnatal Inflammation-Induced Lung Injury in Neonatal BRP-39 Null Mutant Mice Promoting the M1 Macrophage Phenotype

• Main Authors: Mansoor A. Syed (Author), Vineet Bhandari (Author)
• 格式: 圖書
• 出版: Hindawi Limited, 2013-01-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Rationale. Hyperoxia exposure to developing lungs-critical in the pathogenesis of bronchopulmonary dysplasia-may augment lung inflammation by inhibiting anti-inflammatory mediators in alveolar macrophages. Objective. We sought to determine the O2-induced effects on the polarization of macrophages an...