Design, synthesis, molecular docking, and in vitro studies of 2-mercaptoquinazolin-4(3H)-ones as potential anti-breast cancer agents

• Main Authors: Manal A. Alossaimi (Author), Yassine Riadi (Author), Ghaida N. Alnuwaybit (Author), Shadab Md (Author), Huda Mohammed Alkreathy (Author), Engy Elekhnawy (Author), Mohammed H. Geesi (Author), Safar M. Alqahtani (Author), Obaid Afzal (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triple-negative breast cancer (TNBC) comprises 10 % to 20 % of breast cancer, however, it is more dangerous than other types of breast cancer, because it lacks druggable targets, such as the estrogen receptors (ER) and the progesterone receptor (PR), and has under expressed receptor tyrosine kinase,...