TRIM28-Mediated Excessive Oxidative Stress Induces Cellular Senescence in Granulosa Cells and Contributes to Premature Ovarian Insufficiency In Vitro and In Vivo

• Main Authors: Chong Zhou (Author), Dandan Li (Author), Jinxia He (Author), Tao Luo (Author), Yiting Liu (Author), Yue Xue (Author), Jian Huang (Author), Liping Zheng (Author), Jia Li (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Premature ovarian insufficiency (POI) is a clinical syndrome of ovarian dysfunction characterized by the abnormal alteration of hormone levels such as FSH and E₂. POI causes infertility, severe daily life disturbances, and long-term health risks. However, the underlying mechan...