Inhibition of Membrane Na+ Channels by A Type Botulinum Toxin at Femtomolar Concentrations in Central and Peripheral Neurons

• Main Authors: Min-Chul Shin (Author), Masahito Wakita (Author), Du-Jie Xie (Author), Toshitaka Yamaga (Author), Satomi Iwata (Author), Yasushi Torii (Author), Tetsuhiro Harakawa (Author), Akihiro Ginnaga (Author), Shunji Kozaki (Author), Norio Akaike (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent studies have demonstrated that the botulinum neurotoxins inhibit the release of acetylcholine, glutamate, GABA, and glycine in central nerve system (CNS) neurons. The Na+ current (INa) is of major interest because it acts as the trigger for many cellular functions such as transmission, secret...