A transcriptional program associated with cell cycle regulation predominates in the anti-inflammatory effects of CX-5461 in macrophage

• Main Authors: Jie Wang (Author), Zhijian Zheng (Author), Xiaopei Cui (Author), Chaochao Dai (Author), Jiaxin Li (Author), Qunye Zhang (Author), Mei Cheng (Author), Fan Jiang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CX-5461, a novel selective RNA polymerase I inhibitor, shows potential anti-inflammatory and immunosuppressive activities. However, the molecular mechanisms underlying the inhibitory effects of CX-5461 on macrophage-mediated inflammation remain to be clarified. In the present study, we attempted to...