A transcriptional program associated with cell cycle regulation predominates in the anti-inflammatory effects of CX-5461 in macrophage

• Główni autorzy: Jie Wang (Autor), Zhijian Zheng (Autor), Xiaopei Cui (Autor), Chaochao Dai (Autor), Jiaxin Li (Autor), Qunye Zhang (Autor), Mei Cheng (Autor), Fan Jiang (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

CX-5461, a novel selective RNA polymerase I inhibitor, shows potential anti-inflammatory and immunosuppressive activities. However, the molecular mechanisms underlying the inhibitory effects of CX-5461 on macrophage-mediated inflammation remain to be clarified. In the present study, we attempted to...