Systematic analysis of Fc mutations designed to reduce binding to Fc-gamma receptors

• Main Authors: Geoff Hale (Author), Jelle De Vos (Author), Alastair Douglas Davy (Author), Koen Sandra (Author), Ian Wilkinson (Author)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Elimination of the binding of immunoglobulin Fc to Fc gamma receptors is highly desirable for the avoidance of unwanted inflammatory responses to therapeutic antibodies and fusion proteins. Many different approaches have been used in the clinic, but they have not been systematically compared. We hav...