Multitarget Antioxidant NO-Donor Organic Nitrates: A Novel Approach to Overcome Nitrates Tolerance, an Ex Vivo Study

• Main Authors: Elisabetta Marini (Author), Marta Giorgis (Author), Marta Leporati (Author), Barbara Rolando (Author), Konstantin Chegaev (Author), Loretta Lazzarato (Author), Massimo Bertinaria (Author), Marco Vincenti (Author), Antonella Di Stilo (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic use of glyceryl trinitrate (GTN) is limited by serious side effects, such as tolerance and endothelial dysfunction of coronary and resistance arteries. Although GTN is used as a drug since more than 130 years, the mechanisms of the vasodilatory effects and of tolerance development to organic...