Multitarget Antioxidant NO-Donor Organic Nitrates: A Novel Approach to Overcome Nitrates Tolerance, an Ex Vivo Study

• Главные авторы: Elisabetta Marini (Автор), Marta Giorgis (Автор), Marta Leporati (Автор), Barbara Rolando (Автор), Konstantin Chegaev (Автор), Loretta Lazzarato (Автор), Massimo Bertinaria (Автор), Marco Vincenti (Автор), Antonella Di Stilo (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2022-01-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Chronic use of glyceryl trinitrate (GTN) is limited by serious side effects, such as tolerance and endothelial dysfunction of coronary and resistance arteries. Although GTN is used as a drug since more than 130 years, the mechanisms of the vasodilatory effects and of tolerance development to organic...