Direct detection of hemophilia B F9 gene mutation using multiplex PCR and conformation sensitive gel electrophoresis

• Autori principali: Ki Young Yoo (Autore), Hee Jin Kim (Autore), Kwang Chul Lee (Autore)
• Natura: Libro
• Pubblicazione: Korean Pediatric Society, 2010-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Purpose : The F9 gene is known to be the causative gene for hemophilia B, but unfortunately the detection rate for restriction fragment length polymorphism-based linkage analysis is only 55.6%. Direct DNA sequencing can detect 98% of mutations, but this alternative procedure is very...