Role of molecular adsorbent recirculating system in methotrexate-induced acute liver failure: a case report and literature review

• Ngā kaituhi matua: T. Corbisier (Author), André O. Von Bueren (Author), W.B. Breunis (Author), S. Grazioli (Author)
• Hōputu: Pukapuka
• I whakaputaina: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

We describe the case of a 14-year-old girl with osteosarcoma who was treated with high-dose methotrexate (12 g/m2). Twenty-four hours after the infusion, her plasma methotrexate concentration was elevated at 937 μmol/L (normal < 10 µmol/L). She exhibited severe signs of methotrexate toxicity, inc...