The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis

• Main Authors: Paolo Comeglio (Author), Giulia Guarnieri (Author), Sandra Filippi (Author), Ilaria Cellai (Author), Gabriele Acciai (Author), Ian Holyer (Author), Fredrik Zetterberg (Author), Hakon Leffler (Author), Barbro Kahl-Knutson (Author), Erica Sarchielli (Author), Annamaria Morelli (Author), Mario Maggi (Author), Robert J. Slack (Author), Linda Vignozzi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionGalectin-3 is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human KD = 25 nM;...