The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis

• Главные авторы: Paolo Comeglio (Автор), Giulia Guarnieri (Автор), Sandra Filippi (Автор), Ilaria Cellai (Автор), Gabriele Acciai (Автор), Ian Holyer (Автор), Fredrik Zetterberg (Автор), Hakon Leffler (Автор), Barbro Kahl-Knutson (Автор), Erica Sarchielli (Автор), Annamaria Morelli (Автор), Mario Maggi (Автор), Robert J. Slack (Автор), Linda Vignozzi (Автор)
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• Опубликовано: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Предметы: article
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IntroductionGalectin-3 is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human KD = 25 nM;...