Inhibition mechanism of naphthylphenylamine derivatives acting on the CDC25B dual phosphatase and analysis of the molecular processes involved in the high cytotoxicity exerted by one selected derivative in melanoma cells

The dual phosphatases CDC25 are involved in cell cycle regulation and overexpressed in many tumours, including melanoma. CDC25 is a promising target for discovering anticancer drugs, and several studies focussed on characterisation of quinonoid CDC25 inhibitors, frequently causing undesired side tox...

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Main Authors: Federica Aliotta (Author), Rosarita Nasso (Author), Rosario Rullo (Author), Alessandro Arcucci (Author), Angelica Avagliano (Author), Martina Simonetti (Author), Gennaro Sanità (Author), Mariorosario Masullo (Author), Antonio Lavecchia (Author), Maria Rosaria Ruocco (Author), Emmanuele De Vendittis (Author)
Format: Book
Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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