In Silico Screen Identifies a New Family of Agonists for the Bacterial Mechanosensitive Channel MscL

• Asıl Yazarlar: Robin Wray (Yazar), Paul Blount (Yazar), Junmei Wang (Yazar), Irene Iscla (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2022-03-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

MscL is a highly conserved mechanosensitive channel found in the majority of bacterial species, including pathogens. It functions as a biological emergency release valve, jettisoning solutes from the cytoplasm upon acute hypoosmotic stress. It opens the largest known gated pore and has been heralded...