Metronomic 5-Fluorouracil Delivery Primes Skeletal Muscle for Myopathy but Does Not Cause Cachexia

• Auteurs principaux: Dean G. Campelj (Auteur), Cara A. Timpani (Auteur), Tabitha Cree (Auteur), Aaron C. Petersen (Auteur), Alan Hayes (Auteur), Craig A. Goodman (Auteur), Emma Rybalka (Auteur)
• Format: Livre
• Publié: MDPI AG, 2021-05-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Skeletal myopathy encompasses both atrophy and dysfunction and is a prominent event in cancer and chemotherapy-induced cachexia. Here, we investigate the effects of a chemotherapeutic agent, 5-fluorouracil (5FU), on skeletal muscle mass and function, and whether small-molecule therapeutic candidate,...