Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis

• Main Authors: Changqing Xie (Author), Liang Zhong (Author), Hui Feng (Author), Rifu Wang (Author), Yuxin Shi (Author), Yonglin Lv (Author), Yanjia Hu (Author), Jing Li (Author), Desheng Xiao (Author), Shuang Liu (Author), Qianming Chen (Author), Yongguang Tao (Author)
• Format: Book
• Published: Nature Publishing Group, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Oral submucous fibrosis (OSF) is a chronic and inflammatory mucosal disease caused by betel quid chewing, which belongs to oral potentially malignant disorders. Abnormal fibroblast differentiation leading to disordered collagen metabolism is the core process underlying OSF development. The...