Utilization of the chronic atrioventricular block cynomolgus monkey as an in vivo model to evaluate drug interaction-associated torsade de pointes

• Main Authors: Ai Goto (Author), Kengo Sakamoto (Author), Mihoko Hagiwara-Nagasawa (Author), Ryuichi Kambayashi (Author), Koki Chiba (Author), Yoshio Nunoi (Author), Hiroko Izumi-Nakaseko (Author), Akio Matsumoto (Author), Atsushi Sugiyama (Author)
• Format: Book
• Published: Elsevier, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

It has been difficult to experimentally reproduce synergistic effects of ketoconazole on terfenadine-induced torsade de pointes. We assessed proarrhythmic effects of terfenadine (30 mg/kg, p.o.) with/without ketoconazole (100 mg/kg, p.o.) pretreatment using the chronic atrioventricular block cynomol...