Nephrotoxicity of Calcineurin Inhibitors in Kidney Epithelial Cells is Independent of NFAT Signaling

• Asıl Yazarlar: Andrea Karolin (Yazar), Geneviève Escher (Yazar), Stefan Rudloff (Yazar), Daniel Sidler (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Background: Calcineurin inhibitors (CNIs) such as cyclosporine A and tacrolimus are commonly used after renal transplantation to suppress the immune system. In lymphoid cells, cyclosporine A acts via the calcineurin/nuclear factor of activated T-cell (NFAT) axis. In non-lymphoid cells, such as kidne...