Nephrotoxicity of Calcineurin Inhibitors in Kidney Epithelial Cells is Independent of NFAT Signaling

• Main Authors: Andrea Karolin (Author), Geneviève Escher (Author), Stefan Rudloff (Author), Daniel Sidler (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Fag: article
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Background: Calcineurin inhibitors (CNIs) such as cyclosporine A and tacrolimus are commonly used after renal transplantation to suppress the immune system. In lymphoid cells, cyclosporine A acts via the calcineurin/nuclear factor of activated T-cell (NFAT) axis. In non-lymphoid cells, such as kidne...