Identification and optimization of peptide inhibitors to block VISTA/PSGL-1 interaction for cancer immunotherapy

• Main Authors: Xiaoshuang Niu (Author), Menghan Wu (Author), Guodong Li (Author), Xiuman Zhou (Author), Wenpeng Cao (Author), Wenjie Zhai (Author), Aijun Wu (Author), Xiaowen Zhou (Author), Shengzhe Jin (Author), Guanyu Chen (Author), Yanying Li (Author), Jiangfeng Du (Author), Yahong Wu (Author), Lu Qiu (Author), Wenshan Zhao (Author), Yanfeng Gao (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Developing new therapeutic agents for cancer immunotherapy is highly demanding due to the low response ratio of PD-1/PD-L1 blockade in cancer patients. Here, we discovered that the novel immune checkpoint VISTA is highly expressed on a variety of tumor-infiltrating immune cells, especially myeloid d...