Association between Fluoxetine Use and Overall Survival among Patients with Cancer Treated with PD-1/L1 Immunotherapy

• Main Authors: Joseph Magagnoli (Author), Siddharth Narendran (Author), Felipe Pereira (Author), Tammy H. Cummings (Author), James W. Hardin (Author), S. Scott Sutton (Author), Jayakrishna Ambati (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Checkpoint inhibitors can be a highly effective antitumor therapy but only to a subset of patients, presumably due to immunotherapy resistance. Fluoxetine was recently revealed to inhibit the NLRP3 inflammasome, and NLRP3 inhibition could serve as a target for immunotherapy resistance. Therefore, we...