Specificity Protein 1-Mediated Promotion of CXCL12 Advances Endothelial Cell Metabolism and Proliferation in Pulmonary Hypertension

• Main Authors: Evan R. DeVallance (Author), Christopher M. Dustin (Author), Daniel Simoes de Jesus (Author), Imad Al Ghouleh (Author), John C. Sembrat (Author), Eugenia Cifuentes-Pagano (Author), Patrick J. Pagano (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pulmonary arterial hypertension (PAH) is a rare yet devastating and incurable disease with few treatment options. The underlying mechanisms of PAH appear to involve substantial cellular proliferation and vascular remodeling, causing right ventricular overload and eventual heart failure. Recent evide...